Since the introduction of thread-lift sutures, its application has gradually spread among many cosmetic medical specialists (such as plastic surgeons and maxillofacial surgeons) and cosmetic doctors (medical doctors and dentists specialized in noninvasive aesthetic treatments such as botulinum toxin type A and filler injections), with the main indication of lifting sagged tissues by means of a minimally invasive closed procedure. Its application is claimed to be easy after proper training, and it is suggested to be a good alternative for surgical lifts because it is a significantly less invasive procedure. Many colleagues used the technique in the early 1990s but stopped doing so because of disappointing results. Currently, more and more cosmetic doctors offer the procedure; this is the next group of cosmetic treatment providers that will experience the true value of thread-lift sutures. The cosmetic industry has flooded the market with a vastarray of different types of so-called thread-lifting sutures. Substantial amounts of marketing budget have been allocated by these companies to “train” physicians in this procedure. These commercial incentives in combination with enthusiastic cosmetic professionals are mainly responsible for the extensive spread of this supposed minimally invasive lifting procedure. In 2006, Villa et al. published a review article concerning the use of thread-lift sutures for midface elevation.1 The authors concluded that the technique was still in its infancy, but that it had the potential to become a useful and effective procedure as further innovations were made. As 11 years have passed, and based on personal experience with thread-lift sutures, we were curious about the real scientific state of the art on the use of thread-lift sutures and therefore performed a systematic review on this topic.